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POWDERLY WG, SAAG MS, CLOUD GA, et al: A controlled trial of uconazole or amphotericin B to prevent relapse of cryptococcal meningitis in patients with the acquired immunode ciency syndrome N Engl J Med 326:793, 1992 PROANO JV, MADRAZO I, AVELAR F, et al: Medical treatment for neurocysticercosis characterized by giant subarachnoid cysts N Engl J Med 345:879, 2001 QUAGLIARELLO VJ, SCHELD WM: Treatment of bacterial meningitis N Engl J Med 336:708, 1997 REIK L: Spirochetal infections of the nervous system, in Kennedy PGE, Johnson RT (eds): Infections of the Nervous System Boston, Butterworth, 1987, chap 4, pp 43 75 RENNICK G: Cerebral herniation during bacterial meningitis in children BMJ 306:953, 1993 RICH AR: The Pathogenesis of Tuberculosis, 2nd ed Oxford, England, Blackwell, 1951 ROPPER AH, KANIS KB: Flaccid quadriplegia from tonsillar herniation in pneumococcal meningitis J Clin Neurosci 7:330, 2000 ROSENSTEIN NE, PERKINS BA, STEPHENS DS, et al: Meningococcal disease N Engl J Med 344:1378, 2001 ROTHSTEIN TL, KENNY GE: Cranial neuropathy, myeloradiculopathy, and myositis: Complications of Mycoplasma pneumoniae infection Arch Neurol 36:476, 1979 SAAG MS, POWDERLY WG, CLOUD GA, et al: Comparison of amphotericin B with uconazole in the treatment of acute AIDS-associated cryptococcal meningitis N Engl J Med 326:83, 1992 SCADDING JG: Sarcoidosis London, Eyre and Spottiswoode, 1967 SCHUCHAT A, ROBINSON K, WENGER JD, et al: Bacterial meningitis in the United States N Engl J Med 337:970, 1997 SCHWARTZ MA, SELHORST JB, OCHS AL, et al: Oculomasticatory myorhythmia: A unique movement disorder occurring in Whipple disease Ann Neurol 20:677, 1986 SCRIMGEOUR EM, GAJDUSEK DC: Involvement of the central nervous system in Schistosoma mansoni and S haematobium infection Brain 108:1023, 1985 SEIDEL JS, HARMATZ P, VISVESVARA GS, et al: Successful treatment of primary amebic meningoencephalitis N Engl J Med 306:346, 1982 SHERMAN JL, STERN BJ: Sarcoidosis of the CNS: Comparison of unenhanced and enhanced MR images AJNR 11:915, 1990 SHETTY KR, CILVO CL, STARR BD, HARTER DH: Legionnaires disease with profound cerebellar involvement Arch Neurol 37:379, 1980 SILTZBACH LE, JAMES DG, NEVILLE E, et al: Course and prognosis of sarcoidosis around the world Am J Med 57:847, 1974 SLOM TJ, CORTESE MM, GERBER SJ, et al: An outbreak of eosinophilic meningitis caused by Angiostrongylus cantonensis in travelers returning from the Caribbean N Engl J Med 346:688, 2002 SNEDEKER JD, KAPLAN SL, DODGE PR, et al: Subdural effusion and its relationship with neurologic sequelae of bacterial meningitis in infancy: A prospective study Pediatrics 86:163, 1990 SNIDER DE, ROPER WL: The new tuberculosis N Engl J Med 326:703, 1992 SOTELO J, ESCOBEDO F, RODRIGUEZ-CARBAJAL J, et al: Therapy of parenchymal brain cysticercosis with praziquantel N Engl J Med 310:1001, 1984 STERN BJ, KRUMHOLZ A, JOHN SC, et al: Sarcoidosis and its neurological manifestations Arch Neurol 42:909, 1985 SWARTZ MN: Chronic meningitis Many causes to consider N Engl J Med 317:957, 1987 SWARTZ MN, DODGE PR: Bacterial meningitis: A review of selected aspects N Engl J Med 272:725, 779, 842, 898, 1965 THI VA, NORDMANN P, LANDRIEU P: Encephalopathie associee aux infectious bateriennes severes de l enfant: (enephalite presuppurative ou syndrome toxi-infetieux) Rev Neurol 158:709, 2002 THOMPSON RA: Clinical features of central nervous system fungus infection, in Thompson RA, Green JR (eds): Advances in Neurology Vol 6 New York, Raven Press, 1974, pp 93 100 THWAITES GE, BANG ND, DUNG NH, et al: Dexamethasone for the treat-.

ment of tuberculous meningitis in adolescents and adults N Engl J Med 351:1741, 2004 TORO G, ROMAN G: Cerebral malaria Arch Neurol 35:271, 1978 TOWNSEND JJ, WOLINSKY JS, BARINGER JR, JOHNSON PC: Acquired toxoplasmosis Arch Neurol 32:335, 1975 TUNKEL AR, SCHELD WM: Central nervous system infection in the immunocompromised host, in Rubin RH, Young LS (eds): Clinical Approach to Infection in the Compromised Host, 4th ed New York, Kluwer Academic/Plenum, 2002 TUNKEL AR, SCHELD WM: Corticosteroids for everyone with meningitis N Engl J Med 347:1613, 2002 TURNER G: Cerebral malaria Brain Pathol 7:569, 1997 TYLER KL, MARTIN JB: Infectious Diseases of the Nervous System Philadelphia, Davis, 1993 ULDRY PA, KUNTZER T, BOGOUSSLAVSKY J, et al: Early symptoms and outcome of Listeria monocytogenes rhombencephalitis 14 adult cases J Neurol 240:235, 1993

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BIPOLAR TRANSISTORS BEHAVE AS THEY DO BECAUSE CURRENT VARIATIONS AT one P-N junction produce larger current variations at another You ve seen a simplified picture of how this happens, and how the effect can be exploited to get current amplification The bipolar transistor isn t the only way that semiconductors can be combined to get amplification effects The other major category of transistor, besides the bipolar device, is the field-effect transistor or FET There are two main types of FET: the junction FET (JFET) and the metal-oxide FET (MOSFET)

VARTDAL F, VANDVIK B, MICHAELSEN TE, et al: Neurosyphilis: Intrathecal synthesis of oligoclonal antibodies to Treponema pallidum Ann Neurol 11:35, 1982 WALSH TJ, HIER DB, CAPLAN LR: Fungal infections of the central nervous system: Comparative analysis of risk factors and clinical signs in 57 patients Neurology 35:1654, 1985 WASZ-HOCKERT O, DONNER M: Results of the treatment of 191 children with tuberculous meningitis Acta Paediatr 51(Suppl 141):7, 1962 WATT G, ADAPON B, LONG GW, et al: Praziquantel in treatment of cerebral schistosomiasis Lancet 2:529, 1986 WESTENFELDER GO, AKEY DT, CORWIN SJ, VICK NA: Acute transverse myelitis due to Mycoplasma pneumoniae infection Arch Neurol 38:317, 1981 ZUNIGA G, ROPPER AH, FRANK J: Sarcoid peripheral neuropathy Neurology 41:1558, 1991

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A number of viruses share the unique tendency to affect primarily the human nervous system Included in this group are the human immunode ciency viruses (HIV-1 and HIV-2), herpes simplex viruses (HSV-1 and HSV-2), herpes zoster or varicella zoster virus (VZV), Epstein-Barr virus (EBV), cytomegalovirus (CMV), poliovirus, rabies, and several seasonal arthropod-borne viruses Some of these are neurotropic, exhibiting an af nity for certain types of neurons: for example, poliomyelitis viruses and motor neurons, VZV and peripheral sensory neurons, rabies virus and brainstem neurons, and others For many of the rest of the neurotropic viruses, the af nity is less selective in that they involve all elements of the nervous system that is, they are neurohistiopathic Herpes simplex, for example, may devastate the medial parts of the temporal lobes, destroying neurons, glial cells, myelinated nerve bers, and blood vessels; and HIV, the cause of the acquired immunode ciency syndrome (AIDS), may induce multiple foci of tissue necrosis throughout the cerebrum These relationships and many others, which are the subject matter of this chapter, are of wide interest in medicine In many of these conditions, the systemic effects of the viral infection are negligible; it is the neurologic disorder that brings them to medical attention In other words, the neural aspects of viral infection may assume a clinical importance that is disproportionate to the systemic illnesses This aspect of neurology must therefore also be familiar to pediatricians and internists, who are likely to be the rst to see such patients A detailed discussion of viral morphology and cell-virus interactions is beyond the scope of a textbook of neurology Authoritative overviews of this subject can be found in the current edition of Harrison s Principles of Internal Medicine and in the introductory chapters of R T Johnson s monograph Viral Infections of the Nervous System.

A JFET can have any of several different forms They all work the same way: the current varies because of the effects of an electric field within the device The workings inside a JFET can be likened to the control of water flow through a garden hose Electrons or holes pass from the source (S) electrode to the drain (D) This results in a drain current, ID , that is generally the same as the source current, IS This is analogous to the fact that the water comes out of a garden hose at the same rate it goes in (assuming that there aren t any leaks in the hose) The rate of flow of charge carriers that is, the current depends on the voltage at a regulating electrode called the gate (G) Fluctuations in gate voltage, EG, cause changes in the current through the channel, IS or ID Small fluctuations in the control voltage EG can cause large variations in the flow of charge carriers through the JFET This translates into voltage amplification in electronic circuits

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